Assalam-o-alaikum!
Here are my 2 cents:
If you have rectangular panels, having supports (walls, beams, columns) along the edges, the best and recommended way is to provide reinforcement in standard design strips - Column strips 7 Middle Strips (defined in ACI 318-05 Section 13.2).
In SAFE software, slab reinforcement is also distributed in the form of Design Strips, subdivided into Column Strips and Middle Strips. Column strips are detailed for the required negative reinforcement, and the middle strips, for the required positive reinforcement.
For rectangular slab panels, width of column strips is taken as 'span/4' of the two slab spans on either side of support (beam etc) for interior slabs, and 'sum of span/4 for exterior slab span, & the width of shade or cantilever portion' for exterior spans.
In SAFE, each slab panel is subdivided into column and middle strips along both horizontal slab axes (namely, X and Y directions). Widths of various column and middle strips may be checked (and modified, if needed), using specific menu commands. For example, in order to check/modify X-direction design strips, following steps may be used (for SAFE version 8):
1. Go to 'View' -> 'Set X-strip layer'
2. Right-click on the strip to be checked/modified. 'X Design strip' options window will appear.
3. Modify the strip dimensions, if needed.
4. Press OK to make the changes effective.
Process for the Y-strip layer is similar, except that 'Set Y-strip layer' option is to be selected in step-1.
In case the supports are irregularly located, it is still possible to define design strips. For this purpose reference may be made to the following thread:
http://www.sepakistan.com/topic/1635-design-strips-in-safe/
Regards.